Low T Center Low T Center
Find a Location

Find a Location

Use My Current Location

    Erectile Dysfunction Injection Treatment: What is TriMix?

    Posted: November 23, 2021

    If you’re suffering from erectile dysfunction, there are many possible treatment options to choose from. TriMix is a type of medication used for erectile dysfunction injection treatment that works well for many men. Our treatment providers are here to create custom treatment plans based on your lifestyle, which may include TriMix injections for your erectile dysfunction. In this article, we discuss this type of treatment for ED.

    What is Erectile Dysfunction Injection Treatment?

    couple smiling after he began TriMix for erectile dysfunction

    TriMix can help treat erectile dysfunction when other medications don’t work for you.

    Oral medications for erectile dysfunction, such as sildenafil (the generic of Viagra™) and tadalafil (the generic of Cialis™), may not be the right treatment for you. Many men try these medications and find that they don’t improve erectile dysfunction. You may not notice any difference in your symptoms, or symptoms may not improve enough for intercourse. This may be more likely if you have severe ED with underlying conditions like diabetes and hypertension, which can cause significant damage to the blood vessels to your penis. If oral ED drugs don’t work for you, we can explore different treatment options.

    In these cases, our treatment provider may recommend using injectable medications to help reduce erectile dysfunction symptoms. Erectile dysfunction injection treatment involves injecting medications with a syringe into the corpora cavernosa of the penis. Some doctors also call these intracavernosal injections because you inject the medication into the spongy tissues of the corpora cavernosa. TriMix is a common ED injection treatment. It can relax the muscles and open up the blood vessels in your penis responsible for erections.

    What are TriMix Injections for Erectile Dysfunction?

    TriMix injections are a type of erectile dysfunction treatment that many men have good results with. In fact, an estimated 70% of men using TriMix injections report being satisfied with treatment. The name TriMix alludes to the fact that this medication is a mix of three medications frequently used to help improve erectile function. These medications include:

    •       Papaverine
    •       Phentolamine
    •       Prostaglandin E1

    TriMix is a compounded medication that is specially mixed by a qualified pharmacist based on your prescription. When injected into the penis, TriMix can trigger erections and improve erection quality. Unlike many other ED medications, like sildenafil and tadalafil, TriMix injections can even lead to spontaneous erections, which are erections that don’t require sexual stimulation. To understand how TriMix injections work for erectile dysfunction, it’s important to look at what the different medications in TriMix do in the body.


    Papaverine is a medication that helps relax the smooth muscle tissue in the blood vessels. This allows the blood vessels to expand and increase blood flow. This medication has several different medical uses, such as to help with high blood pressure control or treat abnormal heart beats. Papaverine can also help improve erectile function. By injecting papaverine into the corpora cavernosa of the penis, blood vessels that control blood flow to the penis can relax and become wider. This allows more blood to flow into the penis, which can help you achieve and maintain an erection firm enough for sex.


    Phentolamine is a type of alpha blocker that helps your arteries and veins expand and increase blood flow. This medication is sometimes used to help with high blood pressure and hypertensive emergencies, but it can also treat erectile dysfunction. When used in TriMix erectile dysfunction treatments, phentolamine helps improve blood flow to the penis to improve erectile function and erection quality.

    Prostaglandin E1

    Prostaglandin E1 is another medication in TriMix. Another name for this medication is alprostadil. Prostaglandins are actually a type of fat that work in ways similar to hormones because they have different effects based on the receptors they attach to. The prostaglandin E1 found in TriMix injections is man-made to mimic the prostaglandin naturally found in the body. This is another medication that helps smooth muscles in the blood vessels relax and open up to improve blood flow to the penis for those with erectile dysfunction.

    How Does TriMix Injection Therapy Work for Men with Erectile Dysfunction?

    The first step to getting treatment for your erectile dysfunction is visiting one of our treatment providers to talk about your symptoms. In many cases, you may start your treatment with oral medications unless there is another reason you cannot. We may also recommend treating underlying causes of your erectile dysfunction, such as low testosterone or high blood pressure. If these treatments don’t work for you, our providers may recommend TriMix injections.

    Many people feel intimidated by the idea of administering a penile injection to themselves. However, keep in mind that the majority of men using TriMix injections report satisfaction with the treatment. If you’re concerned about pain, most men feel just a small pinch at the injection site. In addition, our team works with you to show you the proper way to give yourself a TriMix injection so you feel comfortable with your erectile dysfunction treatment.

    It’s important to talk to our providers about the specifics of your situation. However, here is some general information about how TriMix therapy typically works.

    TriMix Self Injection for Erectile Dysfunction

    If you have erectile dysfunction, you can give yourself TriMix injections in the comfort of your own home. You’ll learn how to give yourself the TriMix injection step-by-step in the office, but there are a few important things to keep in mind. First, you want to inject the TriMix into the side of the penis. You should avoid the top side, underside, head, and base of the penis. This is because the goal is to inject the medicine into the corpora cavernosa of the penis. A good way to remember this is to give yourself an injection at the 10 o’clock or 2 o’clock position of your penis.

    Generally, doctors recommend waiting at least 24 hours between each dose of TriMix. Also, in most cases, you shouldn’t use TriMix more than three times a week. For erectile dysfunction treatment, you should give yourself an injection 10-30 minutes before sex. After the injection, most men experience an erection within five to 20 minutes. The erection lasts on average between 30 and 60 minutes after injection or up until orgasm.

    Optimizing TriMix Dosage

    Typically, our doctors recommend beginning TriMix injections at the lowest dose and increasing as needed to optimize treatment. Dosage is individualized. However, most providers start TriMix doses at 1.25 micrograms and increasing it as needed. TriMix dosage can go as high as 60 micrograms. Therefore, our team provides ongoing treatment monitoring to adjust doses and treatments to help improve results.

    Erectile Dysfunction Treatment Solutions from Low T Center

    If you’re suffering from erectile dysfunction, our providers at Low T Center offer custom treatment options. We are here to help you prioritize your health as a whole. Our providers offer treatment solutions for many health conditions, including erectile dysfunction, low testosterone, and sleep apnea. We provide quality health care for men at our 41 convenient locations. Make an appointment today to discuss your health and symptoms with our providers. 

    Related Posts

    Disclaimer: This article is made available for general, entertainment and educational purposes only. The opinions expressed herein do not necessarily reflect those of Low T Center. You should always seek the advice of a licensed healthcare professional.