Side Effects

Treatment is recommended for these conditions:

• Symptoms of deficiency or absence of endogenous testosterone.
• Primary hypogonadism (congenital or acquired)-testicular failure due to cryptorchidism, bilateral torsion, orchitis, vanishing testis syndrome; or orchidectomy.
• Hypogonadotropic hypogonadism (congenital or acquired)-idiopathic gonadotropin or LHRH deficiency, or pituitary-hypothalamic injury from tumors, trauma, or radiation.

• You have a known hypersensitivity to the drug
• You are male with carcinoma of the breast
• You are a male with known or suspected carcinoma of the prostate gland
• You have serious cardiac, hepatic or renal disease

• Hypercalcemia may occur in immobilized patients. If this occurs, the drug should be discontinued.
• Prolonged use of high doses of androgens (principally the 17-α alkyl-androgens) has been associated with development of hepatic adenomas, hepatocellular carcinoma, and peliosis hepatis – all potentially life-threatening complications.
• Geriatric patients treated with androgens may be at an increased risk of developing prostatic hypertrophy and prostatic carcinoma although conclusive evidence to support this concept is lacking.
• Edema, with or without congestive heart failure, may be a serious complication in patients with pre-existing cardiac, renal or hepatic disease.
• Gynecomastia may develop and occasionally persists in patients being treated for hypogonadism.
• This product contains benzyl alcohol. Benzyl alcohol has been reported to be associated with a fatal “Gasping Syndrome” in premature infants.
• Androgen therapy should be used cautiously in healthy males with delayed puberty. The effect on bone maturation should be monitored by assessing bone age of the wrist and hand every 6 months. In children, androgen treatment may accelerate bone maturation without producing compensatory gain in linear growth. This adverse effect may result in compromised adult stature. The younger the child, the greater the risk of compromising final mature height.
• This drug has not been shown to be safe and effective for the enhancement of athletic performance. Because of the potential risk of serious adverse health effects, this drug should not be used for such purpose.

You should seek medical attention immediately if symptoms of a heart attack or stroke are present, such as:

• Chest pain
• Shortness of breath or trouble breathing
• Weakness in one part or one side of the body
• Slurred speech

Patients with benign prostatic hypertrophy may develop acute urethral obstruction. Priapism or excessive sexual stimulation may develop. Oligospermia may occur after prolonged administration or excessive dosage. If any of these effects appear, the androgen should be stopped and if restarted, a lower dosage should be utilized. Testosterone Cypionate should not be used interchangeably with testosterone propionate because of differences in duration of action. Testosterone Cypionate is not for intravenous use.

Patients should be instructed to report any of the following: nausea, vomiting, changes in skin color, ankle swelling, too frequent or persistent erections of the penis.

Hemoglobin and hematocrit levels (to detect polycythemia) should be checked periodically in patients receiving long-term androgen administration.

Serum cholesterol may increase during androgen therapy.

Androgens may increase sensitivity to oral anticoagulants. Dosage of the anticoagulant may require reduction in order to maintain satisfactory therapeutic hypoprothrombinemia.

Concurrent administration of oxyphenbutazone and androgens may result in elevated serum levels of oxyphenbutazone.
In diabetic patients, the metabolic effects of androgens may decrease blood glucose and, therefore, insulin requirements.

Animal data
Testosterone has been tested by subcutaneous injection and implantation in mice and rats. The implant induced cervical-uterine tumors in mice, which metastasized in some cases. There is suggestive evidence that injection of testosterone into some strains of female mice increases their susceptibility to hepatoma. Testosterone is also known to increase the number of tumors and decrease the degree of differentiation of chemically induced carcinomas of the liver in rats.

Human data
There are rare reports of hepatocellular carcinoma in patients receiving long-term therapy with androgens in high doses. Withdrawal of the drugs did not lead to regression of the tumors in all cases. Geriatric patients treated with androgens may be at an increased risk of developing prostatic hypertrophy and prostatic carcinoma although conclusive evidence to support this concept is lacking.

Pregnancy
Teratogenic Effects

The following adverse reactions in the male have occurred with some androgens:

• Endocrine and urogenital: Gynecomastia and excessive frequency and duration of penile erections. Oligospermia may occur at high dosages.
• Skin and appendages: Hirsutism, male pattern of baldness, seborrhea, and acne.
• Fluid and electrolyte disturbances: Retention of sodium, chloride, water, potassium, calcium, and inorganic phosphates.
• Gastrointestinal: Nausea, cholestatic jaundice, alterations in liver function tests, rarely hepatocellular neoplasms and peliosis hepatis (see WARNINGS).
• Hematologic: Suppression of clotting factors II, V, VII, and X, bleeding in patients on concomitant anticoagulant therapy, and polycythemia.
• Nervous system: Increased or decreased libido, headache, anxiety, depression, and generalized paresthesia.
• Allergic: Hypersensitivity, including skin manifestations and anaphylactoid reactions.
• Miscellaneous: Inflammation and pain at the site of intramuscular injection.

Each patient’s experience with CPAP is unique, just as each’s patient’s experience with sleeping difficulties are unique. Success involves maintaining proper adjustment of the device and working with your provider, using the unique tools for a personalized experienced provided by Low T Center. Your provider will discuss contraindications and potential side effects of treatment based on your physiology and treatment experience.

Allergy immunotherapy must be carefully performed and monitored. Drugs used in treatment have differing side effects or contraindications so it is important that your treatment be carried out under the supervision of your medical provider. Your provider will discuss possible side effects of testing and treatment that are specific to you, during your visit.

Side effects from thyroid hormone replacement are rare with correct dosing and administration. During this process, you will work with your provider to determine the appropriate dose and method of administration. Your provider will discuss possible side effects and contraindications involved during your visit.

Side effects from cholesterol treatment will vary depending on the method of treatment chosen by your provider. Control through diet, for instance, presents different side effects than control through medication. Your provider will discuss possible side effects and contraindications involved with the treatments recommended during your visit.

Side effects from treating hypertension vary according to your physiology, and the method of treatment chosen by your provider. Your provider will discuss potential side effects and contraindications involved with the treatments recommended during your visit.

Diabetes is typically treated with insulin.  Insulin is a hormone that allows your body to use sugar. Insulin helps keeps your blood sugar level from getting too high (hyperglycemia) or too low (hypoglycemia). Insulin is contraindicated for patients with hypoglycemia, or those who have a demonstrated hypersensitivity to insulin. The most common side effects associated with insulin treatments are headache, weight changes, or allergic reactions. Your Low T Center provider will carefully review your blood chemistry and medical history, fully discuss potential side effects and contraindications for treatment, and work to establish a treatment regimen that is right for you.